Pesquisa | Secretaria de Estado da Saúde

1.

Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.

Simonis, Alexander; Kreer, Christoph; Albus, Alexandra; Rox, Katharina; Yuan, Biao; Holzmann, Dmitriy; Wilms, Joana A; Zuber, Sylvia; Kottege, Lisa; Winter, Sandra; Meyer, Meike; Schmitt, Kristin; Gruell, Henning; Theobald, Sebastian J; Hellmann, Anna-Maria; Meyer, Christina; Ercanoglu, Meryem Seda; Cramer, Nina; Munder, Antje; Hallek, Michael; Fätkenheuer, Gerd; Koch, Manuel; Seifert, Harald; Rietschel, Ernst; Marlovits, Thomas C; van Koningsbruggen-Rietschel, Silke; Klein, Florian; Rybniker, Jan.

Cell ; 186(23): 5098-5113.e19, 2023 11 09.

Artigo Inglês | MEDLINE | ID: mdl-37918395

2.

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.

Kreer, Christoph; Zehner, Matthias; Weber, Timm; Ercanoglu, Meryem S; Gieselmann, Lutz; Rohde, Cornelius; Halwe, Sandro; Korenkov, Michael; Schommers, Philipp; Vanshylla, Kanika; Di Cristanziano, Veronica; Janicki, Hanna; Brinker, Reinhild; Ashurov, Artem; Krähling, Verena; Kupke, Alexandra; Cohen-Dvashi, Hadas; Koch, Manuel; Eckert, Jan Mathis; Lederer, Simone; Pfeifer, Nico; Wolf, Timo; Vehreschild, Maria J G T; Wendtner, Clemens; Diskin, Ron; Gruell, Henning; Becker, Stephan; Klein, Florian.

Cell ; 182(4): 843-854.e12, 2020 08 20.

Artigo Inglês | MEDLINE | ID: mdl-32673567

3.

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Schommers, Philipp; Gruell, Henning; Abernathy, Morgan E; Tran, My-Kim; Dingens, Adam S; Gristick, Harry B; Barnes, Christopher O; Schoofs, Till; Schlotz, Maike; Vanshylla, Kanika; Kreer, Christoph; Weiland, Daniela; Holtick, Udo; Scheid, Christof; Valter, Markus M; van Gils, Marit J; Sanders, Rogier W; Vehreschild, Jörg J; Cornely, Oliver A; Lehmann, Clara; Fätkenheuer, Gerd; Seaman, Michael S; Bloom, Jesse D; Bjorkman, Pamela J; Klein, Florian.

Cell ; 180(3): 471-489.e22, 2020 02 06.

Artigo Inglês | MEDLINE | ID: mdl-32004464

4.

Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.

Korenkov, Michael; Zehner, Matthias; Cohen-Dvashi, Hadas; Borenstein-Katz, Aliza; Kottege, Lisa; Janicki, Hanna; Vanshylla, Kanika; Weber, Timm; Gruell, Henning; Koch, Manuel; Diskin, Ron; Kreer, Christoph; Klein, Florian.

Immunity ; 56(12): 2803-2815.e6, 2023 Dec 12.

Artigo Inglês | MEDLINE | ID: mdl-38035879

5.

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer.

Zehner, Matthias; Alt, Mira; Ashurov, Artem; Goldsmith, Jory A; Spies, Rebecca; Weiler, Nina; Lerma, Justin; Gieselmann, Lutz; Stöhr, Dagmar; Gruell, Henning; Schultz, Eric P; Kreer, Christoph; Schlachter, Linda; Janicki, Hanna; Laib Sampaio, Kerstin; Stegmann, Cora; Nemetchek, Michelle D; Dähling, Sabrina; Ullrich, Leon; Dittmer, Ulf; Witzke, Oliver; Koch, Manuel; Ryckman, Brent J; Lotfi, Ramin; McLellan, Jason S; Krawczyk, Adalbert; Sinzger, Christian; Klein, Florian.

Immunity ; 56(11): 2602-2620.e10, 2023 Nov 14.

Artigo Inglês | MEDLINE | ID: mdl-37967532

6.

Antibody-mediated neutralization of SARS-CoV-2.

Gruell, Henning; Vanshylla, Kanika; Weber, Timm; Barnes, Christopher O; Kreer, Christoph; Klein, Florian.

Immunity ; 55(6): 925-944, 2022 06 14.

Artigo Inglês | MEDLINE | ID: mdl-35623355

7.

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.

Kreer, Christoph; Zehner, Matthias; Weber, Timm; Ercanoglu, Meryem S; Gieselmann, Lutz; Rohde, Cornelius; Halwe, Sandro; Korenkov, Michael; Schommers, Philipp; Vanshylla, Kanika; Di Cristanziano, Veronica; Janicki, Hanna; Brinker, Reinhild; Ashurov, Artem; Krähling, Verena; Kupke, Alexandra; Cohen-Dvashi, Hadas; Koch, Manuel; Eckert, Jan Mathis; Lederer, Simone; Pfeifer, Nico; Wolf, Timo; Vehreschild, Maria J G T; Wendtner, Clemens; Diskin, Ron; Gruell, Henning; Becker, Stephan; Klein, Florian.

Cell ; 182(6): 1663-1673, 2020 09 17.

Artigo Inglês | MEDLINE | ID: mdl-32946786

8.

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

Schoofs, Till; Barnes, Christopher O; Suh-Toma, Nina; Golijanin, Jovana; Schommers, Philipp; Gruell, Henning; West, Anthony P; Bach, Franziska; Lee, Yu Erica; Nogueira, Lilian; Georgiev, Ivelin S; Bailer, Robert T; Czartoski, Julie; Mascola, John R; Seaman, Michael S; McElrath, M Juliana; Doria-Rose, Nicole A; Klein, Florian; Nussenzweig, Michel C; Bjorkman, Pamela J.

Immunity ; 50(6): 1513-1529.e9, 2019 06 18.

Artigo Inglês | MEDLINE | ID: mdl-31126879

9.

SARS-CoV-2 targets neurons of 3D human brain organoids.

Ramani, Anand; Müller, Lisa; Ostermann, Philipp N; Gabriel, Elke; Abida-Islam, Pranty; Müller-Schiffmann, Andreas; Mariappan, Aruljothi; Goureau, Olivier; Gruell, Henning; Walker, Andreas; Andrée, Marcel; Hauka, Sandra; Houwaart, Torsten; Dilthey, Alexander; Wohlgemuth, Kai; Omran, Heymut; Klein, Florian; Wieczorek, Dagmar; Adams, Ortwin; Timm, Jörg; Korth, Carsten; Schaal, Heiner; Gopalakrishnan, Jay.

EMBO J ; 39(20): e106230, 2020 10 15.

Artigo Inglês | MEDLINE | ID: mdl-32876341

10.

Hybrid immunity to SARS-CoV-2 in patients with chronic lymphocytic leukemia.

Mellinghoff, Sibylle C; Robrecht, Sandra; Sprute, Rosanne; Mayer, Leonie; Weskamm, Leonie M; Dahlke, Christine; Gruell, Henning; Teipel, Finn; Schlößer, Hans A; Siepmann, Klara; Thelen, Martin; Fink, Anna-Maria; Fischer, Kirsten; Klein, Florian; Addo, Marylyn M; Kolovou, Androniki; Cornely, Oliver A; Eichhorst, Barbara; Hallek, Michael; Langerbeins, Petra.

Eur J Haematol ; 112(5): 788-793, 2024 May.

Artigo Inglês | MEDLINE | ID: mdl-38311570

11.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Mendoza, Pilar; Gruell, Henning; Nogueira, Lilian; Pai, Joy A; Butler, Allison L; Millard, Katrina; Lehmann, Clara; Suárez, Isabelle; Oliveira, Thiago Y; Lorenzi, Julio C C; Cohen, Yehuda Z; Wyen, Christoph; Kümmerle, Tim; Karagounis, Theodora; Lu, Ching-Lan; Handl, Lisa; Unson-O'Brien, Cecilia; Patel, Roshni; Ruping, Carola; Schlotz, Maike; Witmer-Pack, Maggi; Shimeliovich, Irina; Kremer, Gisela; Thomas, Eleonore; Seaton, Kelly E; Horowitz, Jill; West, Anthony P; Bjorkman, Pamela J; Tomaras, Georgia D; Gulick, Roy M; Pfeifer, Nico; Fätkenheuer, Gerd; Seaman, Michael S; Klein, Florian; Caskey, Marina; Nussenzweig, Michel C.

Nature ; 561(7724): 479-484, 2018 09.

Artigo Inglês | MEDLINE | ID: mdl-30258136

12.

Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody.

Meijers, Matthijs; Vanshylla, Kanika; Gruell, Henning; Klein, Florian; Lässig, Michael.

Proc Natl Acad Sci U S A ; 118(30)2021 07 27.

Artigo Inglês | MEDLINE | ID: mdl-34301904

13.

Rapid Selection of Sotrovimab Escape Variants in Severe Acute Respiratory Syndrome Coronavirus 2 Omicron-Infected Immunocompromised Patients.

Gliga, Smaranda; Lübke, Nadine; Killer, Alexander; Gruell, Henning; Walker, Andreas; Dilthey, Alexander T; Thielen, Alexander; Lohr, Carolin; Flaßhove, Charlotte; Krieg, Sarah; Pereira, Joanna Ventura; Seraphin, Tobias Paul; Zaufel, Alex; Däumer, Martin; Orth, Hans-Martin; Feldt, Torsten; Bode, Johannes G; Klein, Florian; Timm, Jörg; Luedde, Tom; Jensen, Björn-Erik Ole.

Clin Infect Dis ; 76(3): 408-415, 2023 02 08.

Artigo Inglês | MEDLINE | ID: mdl-36189631

14.

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis.

Malin, Jakob J; Weibel, Stephanie; Gruell, Henning; Kreuzberger, Nina; Stegemann, Miriam; Skoetz, Nicole.

J Antimicrob Chemother ; 78(7): 1586-1598, 2023 07 05.

Artigo Inglês | MEDLINE | ID: mdl-37170886

15.

Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections.

Tober-Lau, Pinkus; Gruell, Henning; Vanshylla, Kanika; Koch, Willi M; Hillus, David; Schommers, Philipp; Suárez, Isabelle; Suttorp, Norbert; Sander, Leif Erik; Klein, Florian; Kurth, Florian.

Emerg Infect Dis ; 28(5): 1050-1052, 2022 05.

Artigo Inglês | MEDLINE | ID: mdl-35259088

16.

National medical specialty guidelines of HIV indicator conditions in Europe lack adequate HIV testing recommendations: a systematic guideline review.

Jordans, Carlijn C E; Vasylyev, Marta; Rae, Caroline; Jakobsen, Marie Louise; Vassilenko, Anna; Dauby, Nicolas; Grevsen, Anne Louise; Jakobsen, Stine Finne; Raahauge, Anne; Champenois, Karen; Papot, Emmanuelle; Malin, Jakob J; Boender, T Sonia; Behrens, Georg M N; Gruell, Henning; Neumann, Anja; Spinner, Christoph D; Valbert, Frederik; Akinosoglou, Karolina; Kostaki, Evangelia G; Nozza, Silvia; Giacomelli, Andrea; Lapadula, Giuseppe; Mazzitelli, Maria; Torti, Carlo; Matulionyte, Raimonda; Matulyte, Elzbieta; Van Welzen, Berend J; Hensley, Kathryn S; Thompson, Magdalena; Ankiersztejn-Bartczak, Magdalena; Skrzat-Klapaczynska, Agata; Sandulescu, Oana; Streinu-Cercel, Adrian; Streinu-Cercel, Anca; Miron, Viktor Daniel; Pokrovskaya, Anastasia; Hachfeld, Anna; Dorokhina, Antonina; Sukach, Maryna; Lord, Emily; Sullivan, Ann K; Rokx, Casper.

Euro Surveill ; 27(48)2022 12.

Artigo Inglês | MEDLINE | ID: mdl-36695464

17.

Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals.

Korenkov, Michael; Poopalasingam, Nareshkumar; Madler, Matthias; Vanshylla, Kanika; Eggeling, Ralf; Wirtz, Maike; Fish, Irina; Dewald, Felix; Gieselmann, Lutz; Lehmann, Clara; Fätkenheuer, Gerd; Gruell, Henning; Pfeifer, Nico; Heger, Eva; Klein, Florian.

J Clin Microbiol ; 59(9): e0089621, 2021 08 18.

Artigo Inglês | MEDLINE | ID: mdl-34213977

18.

Relationship between intact HIV-1 proviruses in circulating CD4⁺ T cells and rebound viruses emerging during treatment interruption.

Lu, Ching-Lan; Pai, Joy A; Nogueira, Lilian; Mendoza, Pilar; Gruell, Henning; Oliveira, Thiago Y; Barton, John; Lorenzi, Julio C C; Cohen, Yehuda Z; Cohn, Lillian B; Klein, Florian; Caskey, Marina; Nussenzweig, Michel C; Jankovic, Mila.

Proc Natl Acad Sci U S A ; 115(48): E11341-E11348, 2018 11 27.

Artigo Inglês | MEDLINE | ID: mdl-30420517

19.

Systematic Review and Meta-analysis of Treatment Interruptions in Human Immunodeficiency Virus (HIV) Type 1-infected Patients Receiving Antiretroviral Therapy: Implications for Future HIV Cure Trials.

Stecher, Melanie; Claßen, Annika; Klein, Florian; Lehmann, Clara; Gruell, Henning; Platten, Martin; Wyen, Christoph; Behrens, Georg; Fätkenheuer, Gerd; Vehreschild, Jörg Janne.

Clin Infect Dis ; 70(7): 1406-1417, 2020 03 17.

Artigo Inglês | MEDLINE | ID: mdl-31102444

20.

COVID-19 complicated by parainfluenza co-infection in a patient with chronic lymphocytic leukemia.

Langerbeins, Petra; Fürstenau, Moritz; Gruell, Henning; Klein, Florian; Persigehl, Thorsten; Rybniker, Jan; Seeger-Nukpezah, Tamina; Kochanek, Matthias; Hallek, Michael; Eichhorst, Barbara; Koehler, Philipp; Böll, Boris.

Eur J Haematol ; 105(4): 508-511, 2020 Oct.

Artigo Inglês | MEDLINE | ID: mdl-32575156

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Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer.

Antibody-mediated neutralization of SARS-CoV-2.

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

SARS-CoV-2 targets neurons of 3D human brain organoids.

Hybrid immunity to SARS-CoV-2 in patients with chronic lymphocytic leukemia.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody.

Rapid Selection of Sotrovimab Escape Variants in Severe Acute Respiratory Syndrome Coronavirus 2 Omicron-Infected Immunocompromised Patients.

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis.

Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections.

National medical specialty guidelines of HIV indicator conditions in Europe lack adequate HIV testing recommendations: a systematic guideline review.

Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals.

Relationship between intact HIV-1 proviruses in circulating CD4⁺ T cells and rebound viruses emerging during treatment interruption.

Systematic Review and Meta-analysis of Treatment Interruptions in Human Immunodeficiency Virus (HIV) Type 1-infected Patients Receiving Antiretroviral Therapy: Implications for Future HIV Cure Trials.

COVID-19 complicated by parainfluenza co-infection in a patient with chronic lymphocytic leukemia.